This is scientifically acceptable and in line with relevant guidelines on non-clinical development of vaccine candidates. The report adds, “No carcinogenicity studies were submitted. The low molecular weight of the PEG, the small amount contained in the vaccine and the administration of only few doses do not raise concerns regarding possible accumulation.” Anaphylaxis has been recognised as an established risk, but the responsible antigen is currently unknown and non-IgE mediated allergic reactions remain a possibility.
Currently the involvement of PEG as an antigen triggering allergic reactions is increasingly being recognised. The distribution, metabolism and PK of SM-102 has not been extensively studied but submitted data on a close structural analogue show efficient hydrolysis and clearance. The Moderna vaccine does not contain chloroform when in use but it does use SM-102.įrom the European Medicines Agency assessment report on March 11, 2021, “COVID-19 Vaccine Moderna contains lipid nanoparticles that include two novel lipid components (SM-102, PEG2000-DMG). The molecule helps form the lipid nanoparticles in the Moderna vaccine. SM-102 is a lipid molecule that does not dissolve in water.
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Learn more, read the FDA full Moderna Fact Sheet: įormal Name: 8-amino]-octanoic acid, 1-octylnonyl ester. The remaining ingredients, including acids (acetic acid), acid stabilizers (tromethamine and tromethamine hydrochloride), salt (sodium acetate), and sugar (sucrose) all work together to maintain the stability of the vaccine after it’s produced. Nanolipid components of the Moderna vaccine include: (SM-102, 1,2-dimyristoyl-rac-glycero3-methoxypolyethylene glycol-2000, cholesterol, and 1,2-distearoyl-snglycero-3-phosphocholine ) Lipids: Nanolipids help deliver the mRNA to the vaccine recipient’s cells. MRNA: Like the Pfzer BioNTech vaccine, Moderna’s also uses mRNA technology to build antibodies against COVID-19. Ingredients: messenger ribonucleic acid (mRNA), lipids (SM-102, polyethylene glycol 2000 dimyristoyl glycerol, cholesterol, and 1,2-distearoyl-sn-glycero-3-phosphocholine ), tromethamine, tromethamine hydrochloride, acetic acid, sodium acetate, and sucrose. To determine which zone your address is in, please refer to our Shipping Page for full details.What are the Ingredients in the Moderna Vaccine? Oversize ItemsĪdditional shipping charges for oversize items are calculated on a per product basis based on the chart below. The amount charged is based the weight and shipping distance. Overweight ItemsĪdditional shipping charges for overweight items are calculated based on the total shipping weight of all overweight items. Some of our items are heavy or oversized and may require additional shipping charges. Overweight and oversize additional shipping charges may apply. Live in New England and want your order delivered tomorrow? We offer affordable next-business day service by FedEx including delivery on Saturday for a flat rate of $11.99 for orders under $75, or just $2.99 for orders over $75. New England Next Day Shipping (including Saturday delivery!) Orders under $75 qualify for affordable $8.00 flat rate shipping.
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